HIV nPEP (non-occupational post-exposure prophylaxis)

The clinic offers medications for non-occupational post-exposure prophylaxis of HIV, or nPEP (aka PEPSI). 

nPEP is the emergency use of antiviral medications to reduce the chances of HIV infection after possible exposure through sex or sharing of injection equipment. This is in contrast to occupational post-exposure prophylaxis, which refers to the use of such medication when exposure has occurred in the healthcare setting. nPEP also differs from PrEP (pre-exposure prophylaxis), which is the daily use of medication to prevent infection prior to exposure. 

Use of nPEP may be considered in those who are currently HIV negative and may have been exposed to HIV within the past 72 hours. Under appropriate conditions, nPEP is recommended by many health authorities, including the US Centers for Disease Control and Prevention, the World Health Organisation, the British Association for Sexual Health and HIV (BASHH), and the Australian Society for HIV, Viral Hepatitis and Sexual Health (ASHM). While there are protocols for occupational post-exposure prophylaxis, there are no policy statements or local guidelines regarding nPEP in Japan.

The decision to use nPEP is made on a case-by-case basis, considering the potential risks of infection, adverse effects of taking antiviral medications, and the costs. Please see our HIV nPEP Patient Information Sheet for more details.

If you think you may need nPEP, please call the clinic as soon as possible to arrange for a consultation (03-5432-7177). Following consultation, if the use of nPEP is deemed to be appropriate, medication will be dispensed at the clinic after completing an initial round of blood tests. You will need to return at four weeks and three months for follow up testing.

Please note the following regarding nPEP:

  • The use of antiviral medications for the purpose of nPEP is not an approved indication in Japan
  • nPEP is not 100% effective in preventing infection
  • nPEP is not covered by Japanese National Health Insurance and is expensive (initial cost of ¥220,000~240,000)
  • Payment in full will be required prior to dispensing of medications (credit cards accepted).
  • Medication needs to be taken daily for 28 days
  • Follow-up is crucial to monitor for adverse effects and HIV infection


Please see the following documents for further information: